A natural process where the vitreous undergoes fibrillar degeneration with liquefaction. The gel contained in the vitreous humor turns into liquid from the age of four due to the aggregation of collagen. It can induce age-related nuclear sclerotic cataract due to its inability to consume oxygen, thereby exposing the lens to excess oxidation. It can also lead to open-angle glaucoma and a posterior vitreous detachment, especially as one ages.